Erlotinib In The First Line Treatment Of Non Small Cell Lung Cancer

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Erlotinib in the first line treatment of non small cell lung cancer. A 64 year old woman receives the diagnosis of metastatic non small cell lung cancer nsclc which has progressed during treatment with carboplatin paclitaxel and bevacizumab. Erlotinib has been shown to improve progression free survival compared with chemotherapy when given as first line treatment for asian patients with non small cell lung cancer nsclc with activating egfr mutations. The us food and drug administration fda today approved a companion diagnostic test for erlotinib tarceva an oral cancer drug. Treatment with first line erlotinib was associated with significantly longer progression free survival than was treatment.

1 university of washington pharmaceutical outcomes research and policy program department of pharmacy seattle wa 98195 usa. Erlotinib is an orally administered small molecule inhibitor of epidermal growth factor receptor egfr tyrosine kinase. Lung cancer of which non small cell lung cancer nsclc is the most common form remains the leading cause of cancer related mortality worldwide with many patients presenting with advanced disease at initial diagnosis. A budget impact analysis.

Activating mutations in egfr are important markers of response to tyrosine kinase inhibitor tki therapy in non small cell lung cancer nsclc. Taraeva is indicated for. The treatment of patients with metastatic non small cell lung cancer nsclc whose tumors have epidermal growth factor receptor egfr exon 19 deletions or exon 21 l858r substitution mutations as detected by an fda approved test receiving first line maintenance or second or greater line treatment after progression following. Targeted erlotinib for first line treatment of advanced non small cell lung cancer.

The cobas egfr mutation test detects mutations in the epidermal growth factor receptor egfr gene patients with advanced non small cell lung cancer nsclc who test positive for an egfr mutation may be eligible for erlotinib. Erlotinib can prolong survival in patients with non small cell lung cancer after first line or second line chemotherapy. The optimal study compared efficacy and tolerability of the tki erlotinib versus standard chemotherapy in the first line treatment of patients with advanced egfr mutation positive nsclc. Bajaj ps 1 veenstra dl goertz hp carlson jj.

We aimed to assess the safety and efficacy of erlotinib compared with standard chemotherapy for first line treatment of european patients with advanced egfr mutation.